While I have nothing against the reboot, which everybody seems to be doing, you can expect to find the brand of quippage (which I'm not sure is a real word) Deadpool was known for, thanks to a new writer on board. Not sure what happened in the last issue of Way's Deadpool run, though it seems Deadpool somehow magically regained his healing factor from the reboot. So the logic here is: he never through that horrendous stage of depression, which led to the reinforcement of his suicidal tendencies and from there, his striving to remove all traces of his healing factor so that he could finally commit suicide and embrace Death like any other mortal should. Apparently, the powers that be aren't quite so kind as to let Mr. Deadpool go that easily.
In this issue, Deadpool was hired by SHIELD, or rather, one of the agency's lesser known beings, to resolve a particularly delicate issue which required particularly delicate means to be resolved, and Deadpool here is all about delicateness, n'est-ce pas? Considering that other superheroes have an image to maintain, one which does not involve decapitating dead presidents in the face of the public, it is up to the mercenary to do what's right and of course pays the most, even if it means taking down Franklin D. Roosevelt in a wheelchair. Well, a twisted version of President Roosevelt in a wheelchair anyway.
Well, there's nothing more profound than graphic violence (emphasis on graphic) infused with Deadpool humor to be found in this issue. I would say that it's a nice start.